Boundless Bio

Boundless Bio

What We Do

ecDNA drive many hard-to-treat cancers. We’re exploiting this biology to develop novel medicines to transform cancer outcomes.

Boundless Bio

Boundless Bio

What We Do

ecDNA drive disease progression and resistance. We’re out to make them cancer’s weakest link.

Boundless Bio

Boundless Bio

What We Do

We’re developing medicines to tackle the role of ecDNA in aggressive cancers.

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What We Do

We at Boundless Bio are pioneers in understanding and treating the most intractable cancers. We have charted a new spatial map of the cancer genome within cancer cells and are harnessing our scientific founders’ discoveries about “extrachromosomal DNA,” or ecDNA, to drive a revolution in cancer therapeutics.

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What Are ecDNA?

ecDNA are large circles of DNA containing genes that are outside the cells’ chromosomes and can make many copies of themselves. ecDNA are rarely seen in healthy cells, but are found in nearly half of all solid tumor cancers. ecDNA are thought to be a fundamental driver of cancer growth, resistance, and recurrence.

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Why Boundless Bio?

When DNA in cancer cells comes off chromosomes in the form of ecDNA, it becomes unbound and unwound. This enables cancer-causing genes to replicate and allows cancer cells to grow and resist treatment. With boundless innovation and boundless energy, we aim to develop powerful new cancer medicines that eliminate cancer cells’ ability to employ ecDNA to survive.

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Pioneering Team

We are building a team of pioneers committed to leading a scientific revolution in how the most difficult-to-treat cancers are understood and treated.

Who We Are
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Come Explore With Us

Developing an entirely new class of therapeutics requires boldness, commitment, creativity, and an entrepreneurial spirit. Join our efforts to pioneer medicines that can tackle ecDNA-driven cancers.

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