What We Do
We at Boundless Bio are pioneers in understanding and treating the most intractable cancers. We have charted a new spatial map of the cancer genome within cancer cells and are harnessing our scientific founders’ discoveries about “extrachromosomal DNA,” or ecDNA, to drive a revolution in cancer therapeutics.
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What Are ecDNA?
ecDNA are large circles of DNA containing genes that are outside the cells’ chromosomes and can make many copies of themselves. ecDNA are rarely seen in healthy cells, but are found in nearly half of all solid tumor cancers. ecDNA are thought to be a fundamental driver of cancer growth, resistance, and recurrence.
Learn MoreWhy Boundless Bio?
When DNA in cancer cells comes off chromosomes in the form of ecDNA, it becomes unbound and unwound. This allows cancer-causing genes to replicate and become highly transcriptionally active, which in turn enables cancer cells to grow and resist treatment. With boundless innovation and boundless energy, we aim to develop powerful new cancer medicines that eliminate cancer cells’ ability to employ ecDNA to survive.
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Pioneering Team
We are building a team of pioneers committed to leading a scientific revolution in how the most difficult-to-treat cancers are understood and treated.
Who We AreCome Explore With Us
Developing an entirely new class of therapeutics requires boldness, commitment, creativity, and an entrepreneurial spirit. Join our efforts to pioneer medicines that can tackle ecDNA-driven cancers.
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