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Unbound by convention, bound to save lives

Join Our Team

Developing an entirely new class of therapeutics requires boldness, commitment, creativity, and entrepreneurial spirit. Join us in tackling ecDNA-driven cancers to pioneer medicines for treating the most difficult-to-treat cancers.

We seek innovative, passionate, and motivated team members to help transform exciting ecDNA discoveries into cancer medicines of the future. Come join us in the next revolution of helping patients with cancer!

Core Values

Boldness

We not only want to, but believe that we can, achieve unprecedented things--it is our base case assumption that we will, employing passion, innovation, and urgency to propel us.

Commitment

We are devoted and accountable to each other, our products and our patients. We take pride in seeing a task through to completion, on time, giving 100% of ourselves along the way. We value those who relentlessly find a way to obtain answers and propose solutions, without accepting no as an answer.

Quality

Because we are in the business of generating novel molecules to be dosed to patients, extreme dedication to quality—of product and character—pervades everything we do. No product, task, or interaction that we engage in receives anything less than our utmost care and integrity.

Collaboration

As a cell is a complex organism that relies on different components functioning in an integrated manner to thrive, so too is a vibrant biotechnology company. All disciplines are interdependent and must operate in lockstep teamwork for our company organism to succeed.

Transparency

All data, facts and opinions must be revealed and communicated to enable fully informed decision-making under otherwise murky circumstances. We all have an obligation to speak up and to listen. All inputs are considered.

Compassion

We care deeply about our fellow human beings, including our colleagues, business partners, and customers (patients and physicians). We welcome diversity, we seek to understand each other, and we embrace our differences, without judgment.

Open

Positions

Associate Director/Director Bioinformatics

Job Description

As an Associate Director/Director, Bioinformatics at Boundless Bio, you will play a significant role in helping us transform exciting ecDNA discoveries into the next generation of cancer medicines.  As part of a collaborative team, you will be a lead member of the bioinformatics function instrumental in supporting biology, drug development, chemistry, and diagnostics, projects through hypothesis-driven data analysis, curation and analytical tool development.

About The Role

  • Essential duties and responsibilities include the following. Other duties may be assigned.
  • Integrate with biology and diagnostic teams to ensure relevant analyses are executed and reported in a timely manner.
  • Communicate with leadership team and team members on status of ongoing projects and completed analyses.
  • Develop interfaces and presentations that clearly report data results to non-computational scientists and non-scientists.
  • Apply statistical models to large data sets to test biological hypotheses.
  • Data collation and analysis for all Boundless Bio studies (e.g., combining CRISPR data with Mass Spec data, etc). Studying patterns within and across data sets.
  • Develop new and/or improved software tool for the identification of ecDNA.
  • Propose or inform new laboratory studies based on results of analyses.
  • Act as cross-functional point of contact between Boundless Bio scientific team(s) and external data analysis teams.
  • Understanding the pitfalls and challenges of current clinical testing platforms for the assessment of ecDNA or proxy markers (e.g., CNV).
  • Data mining of existing data sets for ecDNA driven tumor types, signatures, or targets.
  • Perform all duties in keeping with the Company’s core values, policies and all applicable regulations.

Responsibilities

Minimum Requirements:

  • Advanced degree:  Minimum of 5 years related industry experience; or equivalent.
  • Highly collaborative with proven experience managing projects across teams/functions.
  • Experience with analyzing NGS data generated typical commercial platforms (e.g., Illumina)
  • Proficiency at Python, Perl, and R scripting languages.
  • Proficiency at Red Hat Linux, Windows, and Mac OS X environments.
  • Experience with using statistical models and analytical tools to evaluate biological hypotheses.
  • Experience data-mining population/cohort data sets for correlations, signals and signatures.
  • Strong written communications skills with meticulous attention to detail
  • Effective presentation and interpersonal communication skills.

 

Desired:

  • Experience working in a regulated (e.g., CLIA and GxP) environment.
  • Experience analyzing DNA-Seq, RNA-Seq, ChIP-Seq, and BS-Seq data sets.

Experience working on a drug development project team.

Associate Director/Director Chemistry

Job Description

As an Associate Director/Director, Chemistry at Boundless Bio, you will play a significant role in helping us transform exciting ecDNA discoveries into the next generation of cancer medicines.  Using a range of chemistry techniques, primarily synthetic organic chemistry, structure-based drug design, and data analysis tools, you’ll design and create new pharmaceutically active molecules to support the Boundless Bio drive for innovation. You will have management responsibilities and direct oversight of activities or CRO’s and will be working closely within a multidisciplinary team to integrate biological, DMPK and formulation data to accelerate lead optimization to deliver clinical candidates. The AD/Director, Chemistry will also manage and support daily lab operation.

About The Role

Essential duties and responsibilities include the following.  Other duties may be assigned.

  • Responsible for the oversight, leadership, and implementation of Boundless Bio’s drug discovery programs.
  • Design novel small molecule drug candidates for in vitro/in vivo biological studies with the goal of providing proprietary clinical candidates.
  • Manage 1-3 direct reports.
  • Manage and oversees CRO activities and contractual relationship.
  • Encourage collaboration with external partners and build strong external networks.
  • Understand and incorporate pharmacological data in the design of novel small molecule drugs.
  • Design synthetic routes to novel molecules which are robust, versatile and efficient.
  • Carry out job responsibilities and assignments safely and maintain a clean and safe work area.
  • Maintain research records and lab notebooks in a concise, legible and complete manner.
  • Make and deliver presentations to management, scientific advisory board and consultants.
  • Represents the company externally in scientific meetings and congresses.
  • Demonstrated experience functioning within strong multi-disciplinary project teams.
  • Perform all duties in keeping with Boundless Bio’s core values, policies, and all applicable regulations.

Responsibilities

Minimum Requirements:

  • D. or MS in Synthetic Organic or Medicinal Chemistry
  • 5+ years of industrial experience in Drug Discovery & Development
  • Demonstrated success working in a collaborative team environment.
  • Strong written and interpersonal communication skills.
  • Management experience directing the activities of a chemistry team
  • Ability to manage multiple projects in a fast-paced environment.
  • Ability to carry out investigations, performing experiments independently while obtaining accurate data and maintaining excellent laboratory records.
  • Ability to communicate effectively and work in team-based environment.
  • Ability to co-ordinate efforts with CROs as well as internal multi-disciplinary teams.
  • Experience working with legal functional group designing IP strategy as well as drafting and filing patents where the candidate is a lead or co-inventor
  • Experience preparing and presenting data package to potential investors or potential clinical partners

Desired:

  • Successful track record in a drug discovery environment, including advancing at least one program from hit to lead candidate.
  • Experience with structure-based drug design.
Apply Now

Research Associate/Sr. Research Associate

Job Description

As a Research Associate at Boundless Bio, you will play a significant role in helping us transform exciting ecDNA discoveries into the next revolution of cancer medicines.  You will perform technical and laboratory tasks to support assay development projects for use in target identification, target validation, basic biology, diagnostic, and/or clinical testing applications. As part of a collaborative team, you will design and execute laboratory experiments and testing programs, evaluate test data, and prepare associated documentation, presentations and reports to support the Boundless Bio drive for innovation.

About The Role

  • Design, execute, and troubleshoot new procedures and assays for new project initiatives and/or offerings.
  • Perform tissue culture work for experiments and to maintain Boundless Bio inventory, including: Developing stable cell lines, mammalian cell transection, viral transfection/infection, and protein purification.
  • Conduct experiments using a variety of biology lab methods, including, but not limited to:  Immunoassays, ELISA, flow cytometry, western blotting, nucleic acid extraction, PCR, qPCR.
  • Identify and troubleshoot problems that may adversely affect test performance/results.
  • Perform initial analysis on designed experiments and contribute to decisions for assay optimization.
  • Work in conjunction with internal department staff, external resources, and/or collaborators as needed to obtain/share information and execute project.
  • Train and assist new staff with technical and operational procedures.
  • Contribute to peer reviewed publications, posters, and meeting presentations.
  • Perform all duties in keeping with the Company’s core values, policies, and all applicable regulations.

Responsibilities

  • Bachelor’s degree in Biological Sciences or related scientific discipline with minimum 2+ years of experience.
  • Demonstrated experience with typical laboratory platforms (e.g. Immunoassays, ELISA, flow cytometry, western blotting, nucleic acid extraction, PCR, qPCR).
  • Experience with tissue culture techniques and storage methods.
  • Experience working in controlled laboratory environments is desired.
  • Meticulous attention to detail with strong reasoning and problem-solving skills in experimental design, data analysis, verification, manipulation and interpretation.
  • Demonstrated understanding of, and ability to apply principles, concepts, practices and standards associated with analytical assay development/validation and/or sample testing in a laboratory setting.
  • Demonstrated success working in a collabortive team environment.
  • Strong written and interpersonal communication skills.
  • Ability to manage multiple projects in a fast-paced environment.
  • Knowledge of statistical methods is desirable.
Apply Now

At Boundless Bio, our employees are advancing their careers by working on pioneering science. Each team member makes an impact and contributes to our vision every day. We collaborate, we move nimbly, and we are passionate about the meaningful work we do on behalf of patients with intractable cancers.

Meredith Wesley

VP, Talent and Culture

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