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Unbound by convention, bound to save lives

Join Our Team

Developing an entirely new class of therapeutics requires boldness, commitment, creativity, and entrepreneurial spirit. Join us in tackling ecDNA-driven cancers to pioneer medicines for treating the most difficult-to-treat cancers.

We seek innovative, passionate, and motivated team members to help transform exciting ecDNA discoveries into cancer medicines of the future. Come join us in the next revolution of helping patients with cancer!

Core Values

Boldness

We not only want to, but believe that we can, achieve unprecedented things--it is our base case assumption that we will, employing passion, innovation, and urgency to propel us.

Commitment

We are devoted and accountable to each other, our products and our patients. We take pride in seeing a task through to completion, on time, giving 100% of ourselves along the way. We value those who relentlessly find a way to obtain answers and propose solutions, without accepting no as an answer.

Quality

Because we are in the business of generating novel molecules to be dosed to patients, extreme dedication to quality—of product and character—pervades everything we do. No product, task, or interaction that we engage in receives anything less than our utmost care and integrity.

Collaboration

As a cell is a complex organism that relies on different components functioning in an integrated manner to thrive, so too is a vibrant biotechnology company. All disciplines are interdependent and must operate in lockstep teamwork for our company organism to succeed.

Transparency

All data, facts and opinions must be revealed and communicated to enable fully informed decision-making under otherwise murky circumstances. We all have an obligation to speak up and to listen. All inputs are considered.

Compassion

We care deeply about our fellow human beings, including our colleagues, business partners, and customers (patients and physicians). We welcome diversity, we seek to understand each other, and we embrace our differences, without judgment.

Open

Positions

Associate Director/Director Chemistry

Job Description

As an Associate Director/Director, Chemistry at Boundless Bio, you will play a significant role in helping us transform exciting ecDNA discoveries into the next generation of cancer medicines.  Using a range of chemistry techniques, primarily synthetic organic chemistry, structure-based drug design, and data analysis tools, you’ll design and create new pharmaceutically active molecules to support the Boundless Bio drive for innovation. You will have management responsibilities and direct oversight of activities or CRO’s and will be working closely within a multidisciplinary team to integrate biological, DMPK and formulation data to accelerate lead optimization to deliver clinical candidates. The AD/Director, Chemistry will also manage and support daily lab operation.

About The Role

Essential duties and responsibilities include the following.  Other duties may be assigned.

  • Responsible for the oversight, leadership, and implementation of Boundless Bio’s drug discovery programs
  • Design novel small molecule drug candidates for in vitro/in vivo biological studies with the goal of providing proprietary clinical candidates
  • Manage and oversees CRO activities and contractual relationship
  • Encourage collaboration with external partners and build strong external networks
  • Understand and incorporate pharmacological data in the design of novel small molecule drugs
  • Design synthetic routes to novel molecules which are robust, versatile and efficient
  • Carry out job responsibilities and assignments safely and maintain a clean and safe work area
  • Maintain research records and lab notebooks in a concise, legible and complete manner
  • Design and deliver presentations to management, scientific advisory board and consultants
  • Represents the company externally in scientific meetings and congresses
  • Manage 1-3 direct reports
  • Perform all duties in keeping with Boundless Bio’s core values, policies, and all applicable regulations

Responsibilities

Minimum Requirements:

  • D. or MS in Synthetic Organic or Medicinal Chemistry
  • 5+ years of industrial experience in Drug Discovery & Development
  • Demonstrated success working in a collaborative team environment
  • Strong written and interpersonal communication skills
  • Management experience directing the activities of a chemistry team
  • Ability to manage multiple projects in a fast-paced environment
  • Ability to carry out investigations, performing experiments independently while obtaining accurate data and maintaining excellent laboratory records
  • Ability to communicate effectively and work in team-based environment
  • Ability to co-ordinate efforts with CROs as well as internal multi-disciplinary teams
  • Experience working with legal functional group designing IP strategy as well as drafting and filing patents where the candidate is a lead or co-inventor
  • Experience preparing and presenting data package to potential investors or potential clinical partners

Desired:

    • Successful track record in a drug discovery environment, including advancing at least one program from hit to lead candidate
    • Experience with structure-based drug design
Apply Now

Research Associate/Sr. Research Associate, Biology

Job Description

As a Research Associate at Boundless Bio, you will play a significant role in helping us transform exciting ecDNA discoveries into cancer medicines of the future.  You will perform technical and laboratory tasks to support assay development projects for eventual use in target identification, target validation, basic biology, diagnostic, and/or clinical testing applications. As part of a collaborative team, you will design and execute laboratory experiments and testing programs, evaluate test data, and prepare associated documentation, presentations and reports to support the Boundless Bio drive for innovation.

About The Role

  • Design, execute, and troubleshoot new procedures and assays for new project initiatives and/or offerings
  • Perform tissue culture work for experiments and to maintain Boundless Bio inventory, including: Developing stable cell lines, mammalian cell transfection, viral transduction, and protein purification
  • Conduct experiments using a variety of biology lab methods, including, but not limited to: Immunoassays, ELISA, flow cytometry, western blotting, nucleic acid extraction, PCR, qPCR, CRISPR
  • Identify and troubleshoot problems that may adversely affect test performance/results
  • Perform initial analysis on designed experiments and contribute to decisions for assay optimization
  • Work in conjunction with internal department staff, external resources, and/or collaborators as needed to obtain/share information and execute project
  • Train and assist new staff with technical and operational procedures
  • Contribute to peer reviewed publications, posters, and meeting presentations
  • Perform all duties in keeping with the Company’s core values, policies, and all applicable regulations

Responsibilities

  • Bachelor’s degree in Biological Sciences or related scientific discipline with minimum 2+ years of experience
  • Demonstrated experience with typical laboratory platforms (e.g. Immunoassays/immunohistochemistry/immunofluorescence, ELISA, flow cytometry, western blotting, nucleic acid extraction, PCR, qPCR, siRNA, shRNA)
  • Experience with tissue culture techniques and storage methods
  • Experience working in controlled laboratory environments is desired
  • Meticulous attention to detail with strong reasoning and problem-solving skills in experimental design, data analysis, verification, manipulation and interpretation
  • Demonstrated understanding of, and ability to apply principles, concepts, practices and standards associated with analytical assay development/validation and/or sample testing in a laboratory setting
  • In vivo experience (e.g., xenograft, dosing, experimental design, etc.) a plus
  • Demonstrated success working in a collaborative team environment
  • Strong written and interpersonal communication skills
  • Ability to manage multiple projects in a fast-paced environment
  • Knowledge of statistical methods is desirable
Apply Now

Research Associate/Sr. Research Associate, Chemistry

Job Description

As a Research Associate/Senior Research Associate at Boundless Bio, you will play a significant role in helping us transform exciting ecDNA discoveries into cancer medicines of the future.  As part of an integrated drug discovery team, you will design and synthesize compounds against ecDNA targets to support the Boundless Bio drive for innovation.

About The Role

  • Design and synthesize small molecule compounds
  • Analyze and interpret data sets to develop understanding of SAR
  • Independently design and perform experiments and procedures with moderate degree of complexity, demonstrating expertise with a wide range of techniques
  • Demonstrates flexibility in adapting methods/skills according to evolving project priorities
  • Present results in lab and internal meetings
  • Accurately document experiments in lab notebook
  • Contribute to writing of reports and patents
  • Work collaboratively across functions
  • Perform all duties in keeping with the Company’s core values, policies, and all applicable regulations

Responsibilities

Education/Experience

    • BS or MS in chemistry or related field and 2+ years’ experience conducting small molecule synthesis, independent drug discovery, or related laboratory research
    • Demonstrated synthetic chemistry experience in multistep synthesis and purification of small organic molecules
    • Demonstrated experience designing and executing synthetic schemes
    • In-depth knowledge and fundamental understanding of modern characterization techniques (NMR, LCMS, etc.)

Knowledge, Skills, and Abilities

    • Possess strong synthetic and technical skills in chemistry
    • Demonstrated ability to analyze, interpret and present results in internal meetings
    • Work independently as well as collaborate in a team environment
    • Ability to analyze and resolve issues of moderate complexity
    • Ability to troubleshoot and optimize reaction conditions
    • Possess strong attention to detail and organizational skills
    • Demonstrate professional communication and interpersonal skills
    • Ability to search literature databases (Reaxys, SciFinder)
Apply Now

Sr. Scientist/ Principal Scientist

Job Description

As a Scientist at Boundless Bio, you will play a significant role in helping us transform exciting ecDNA discoveries into cancer medicines of the future. You will be responsible for designing, executing, and analyzing experiments to address fundamental structure and function of extrachromosomal DNA (ecDNA) as well as to identify and validate potentially druggable targets implicated in ecDNA-driven cancer cell growth. Additional roles may include translation of experimental findings into screening and mechanism of action assays to discover and develop drugs that halt the growth of amplified oncogene-driven human cancers. This is an excellent opportunity for a highly motivated self-starter and creative problem solver with a strong desire to make an important contribution to the development of novel therapeutics in an area of cutting-edge cancer biology.

About The Role

  • Utilize conventional and cutting-edge techniques and analyses to evaluate ecDNA-related oncology target and pathway biology
  • Develop and design hypothesis-generating and hypothesis-testing experiments for target identification and validation
  • Establish target screening assays and protocols for identification and validation of potential targets (e.g., RNAi/CRISPR studies)
  • Establish screening assays for drug discovery
  • Develop and apply higher order models for hit-to-lead optimization and mechanism of action studies
  • Write reports and present results and project assessments to Senior Management
  • Generate publications and poster presentations to educate the scientific community at large regarding Boundless discoveries and advancement of the field
  • Evaluate, establish, and manage external collaborations with academics and CROs

Responsibilities

  • Ph.D. in cancer biology, genetics, biochemistry, molecular or cellular biology, preferred with 5+ years of relevant experience; At least 2 years industry experience is strongly preferred
  • Experience in drug development; Target ID/validation experience strongly preferred
  • Excellent written communication skills
  • Excellent presentation and interpersonal communication skills
  • Strong scientific credentials as evidenced by high-caliber publications and patents, or key contribution in industry R&D programs
  • Proven track record in a team-oriented, fast-paced environment at a dynamic and growing company
  • Highly organized, self-directed, and detail oriented with excellent communication skills
  • Strong scientific understanding and hands-on experience in the following areas are highly desirable:
      • Advanced cellular, molecular biology and tissue culture techniques
      • Genetic techniques/analysis methods (RNAi, CRISPR, FISH)
      • Signaling pathway analysis
      • Assay development (HTS/HCS, FRET/AlphaScreen, enzymatic, ELISA)
      • Protein expression and analysis (immunoblot, immunofluorescence, IHC, etc.)
      • Lab automation equipment and microscopy
Apply Now

At Boundless Bio, our employees are advancing their careers by working on pioneering science. Each team member makes an impact and contributes to our vision every day. We collaborate, we move nimbly, and we are passionate about the meaningful work we do on behalf of patients with intractable cancers.

Meredith Wesley

VP, Talent and Culture

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