1/27/25
Preclinical and Phase 1/2 Data of the CHK1 Inhibitor BBI-355 in Development for Esophageal and Gastric Cancers (EGC) with EGFR or FGFR2 Amplifications
From ASCO Gastrointestinal Cancers Symposium 2025
Read more11/6/2024
Enhancing transcription–replication conflict targets ecDNA-positive cancers
From Nature
Read More11/6/2024
Coordinated inheritance of extrachromosomal DNAs in cancer cells
From Nature
Read More11/6/2024
Origins and impact of extrachromosomal DNA
From Nature
Read More9/14/2024
Mapping extrachromosomal DNA amplifications during cancer progression
From Nature Genetics
Read More4/12/2023
Extrachromosomal DNA in the cancerous transformation of Barrett’s oesophagus
From Nature
Read More10/17/2022
Targeted profiling of human extrachromosomal DNA by CRISPR-CATCH
From Nature
Read More9/18/2022
The evolutionary dynamics of extrachromosomal DNA in human cancers
From Nature Genetics
Read More8/11/2022
Extrachromosomal DNA amplifications in cancer
From Nature Reviews Genetics
Read More8/10/2022
Gene regulation on extrachromosomal DNA
From Nature Structural & Molecular Biology
Read More2/9/2022
Mapping clustered mutations in cancer reveals APOBEC3 mutagenesis of ecDNA
From Nature
Read More11/24/2021
ecDNA hubs drive cooperative intermolecular oncogene expression
From Nature
Read More6/24/2021
Acquired Resistance to KRAS glycine-to-cysteine amino acid substitutions at codon 12 Inhibition in Cancer
From NEJM
Read More8/17/2020
Extrachromosomal DNA is associated with oncogene amplification and poor outcome across multiple cancers
From Nature Genetics
Read More5/13/2020
Extrachromosomal DNA (ecDNA) carrying amplified oncogenes as a biomarker for insensitivity to checkpoint inhibitor treatment in gastric cancer patients.
From ASCO
Read More1/6/2020
Circular DNA Throws Gene Regulation for a Loop
From Cancer Discovery
Read More11/20/19
Circular ecDNA promotes accessible chromatin and high oncogene expression
From Nature
Read More3/14/2019
Extrachromosomal oncogene amplification in tumor pathogenesis and evolution
From Nature Reviews Cancer
Read More2/8/2017
Extrachromosomal oncogene amplification drives tumor evolution and genetic heterogeneity
From Nature
Read More1/3/2014
Targeted therapy resistance mediated by dynamic regulation of extrachromosomal mutant EGFR DNA
From Science
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